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Tuesday22 August 2017

Why Tomography

The Role of Tomotherapy in HITV

Computed Tomography

In HITV, it is hypothesized that radiation would lower the tumor burdens, decrease the number and function of regulatory cells in the tumor environment and release products of tumor cells that could be acquired by intratumoral injected immature dendritic cells ( iDC ).

Why Tomotherapy

Tomotherapy has the ability deliver Image Guided Radiotherapy ( IMRT ). With the advancement of radiation technology, IMRT allows control of the radiation intensity delivered to the tumor during treatment. This allows a higher dose of radiation to be delivered precisely to the tumor tissue and spare the adjacent healthy tissues from unnecessary high exposure to radiation.

The panel on top shows the radiation dose distribution using Tomotherapy while the bottom panel shows dose distribution for 3D conformal radiotherapy.

It can be seen quite clearly the superior radiation dose intensity control demonstrated by the Tomotherapy by concentrating high dose ( Red area ) on tumor tissue and lower dose on adjacent tissues ( Green and Blue areas )

Tomo dose distribution[ Source : ‘A comparison of radiation treatment plans using IMRT with helical tomotherapy and 3D conformal radiotherapy for nasal natural killer/T-cell lymphoma’. BJR September 1, 2009 vol. 82 no. 981 756-763 ]

How is Computed Tomography used in cancer? *

Computed tomography is used in several ways :

  • To detect or confirm the presence of a tumor
  • To provide information about the size and location of the tumor and whether it has spread
  • To guide a biopsy ( the removal of cells or tissues for examination under a microscope )
  • To help plan radiation therapy or surgery
  • To determine whether the cancer is responding to treatment

* National Cancer Institute

HITV Lab

HITV Lab is involved in cell-based biotechnology medical applications with special focus on Dendritic Cell-Based Immunotherapy for cancer. HITV Lab is committed to support an international collaboration in the FDA clinical trial of HITV Therapy in late-stage cancer patients led by the University of Maryland, USA.

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